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A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade GliomaArginine Deprivation Therapy in Recurrent High-grade Gliomas

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Adding amylin agonism to a dual or triple incretin agonist is mechanistically plausible, but the concern is stacked gastrointestinal burden: adding semaglutide alone pushed GI events from 54.0% to 79.6%, and discontinuations from 2.6% to 5.9%

Donepezil ameliorates A pathology but not tau pathology in 5xFAD mice

Increased monocyte oxidase activity in cystic fibrosis heterozygotes and homozygotes