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[2] Cobalamin (vitamin B12) : Has not been found to directly affect the GLP-1 hormone

Allergan Aesthetics says it has been studying the intersection of medical weight loss and aesthetic medicine since 2022, including research presented at the 2025 American Society for Dermatologic Surgery Annual Meeting and a January 2026 publication in Aesthetic Surgery Journal Open Forum examining nonsurgical facial treatments for patients using GLP-1 receptor agonists

However, Methylcobalamin offers several added benefits compared to cyanocobalamin, particularly due to its bioavailability and direct usability in the body

Another avenue is considering enrolling in a clinical trial for newer weight loss meds some trials provide medication at no cost

A phase 2 trial published in the New England Journal of Medicine reported substantial average weight reduction in adults with obesity or overweight