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Abstract Glucagon-like peptide-1 (GLP-1) is a gut-derived hormone essential for maintaining glucose homeostasis through multiple physiological pathways: triggering insulin release, inhibiting glucagon secretion, delaying gastric emptying, enhancing feelings of fullness, and suppressing appetite

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Thus, depression in T2DM may stem from metabolic dysfunctions/MetS alongside diminished PON1 and HDL-C levels

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