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Figure 3 As mentioned previously, GSH, a tripeptide containing glutamate, cysteine and glycine, (L--glutamyl-L-cysteinyl-glycine) is the master and most potent cellular antioxidant and the most abundant low molecular weight thiol that plays a crucial role in antioxidant defense against cellular ROS/reactive nitrogen species (RNS)-mediated oxidative damage and in the regulation of numerous metabolic pathways essential for maintaining whole body homeostasis
Adopting a diet rich in sulfur-containing vegetables and getting regular physical activity can further enhance its cellular benefits
We further revealed a pivotal role of immune response regulated by TGF- pathway in contributing to lifespan extension following mrps-5 RNAi, providing additional understanding of the mechanism and underscoring the beneficial effects of mitochondrial translation repression
Price et al
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