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If youre noticing reflux alongside other GLP-1 side effects, our overview of GLP-1 side effects in 2026 covers the broader picture

"One disappointing aspect is that a patient might get started on these drugs, then they might stop for a month or two and then they might find another company that pops up that might give them these medications and all the while, no one's really addressing what's going on holistically with these types of patients who actually probably need to get plugged in and need to get an appropriate workup and diagnosis to make sure it's appropriate and get that kind of whole person care," she said

This also reduces the metabolic adaptation (adaptive thermogenesis) that can plateau weight loss later

For most, it's part of a combined approach

For example, specific taxa in the Bacteroidetes phylum, especially Bacteroides species, have been found to affect GLP-1 secretion through the generation of SCFAs like acetate and propionate [126,127]