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The CIR (Cosmetic Ingredient Review) has concluded this ingredient to be safe as used in cosmetics and it has not shown to be a skin sensitizer in testing (unless you have a known rice allergy)

CagriSema: GI adverse events affected 79.6% in the CagriSema group vs 39.9% placebo in REDEFINE 1, including nausea, vomiting, diarrhea, constipation, and abd

There is no strong human evidence that they do