To integrate possible mechanistic events, a unified proposal for the role of cuproptosis in Wilson disease is suggested: (1) Published data support that copper ions induce oxidative stress by generating ROS, including hydroxyl radicals and H 2 O 2 , via the Haber-Weiss and Fenton reactions [21,27,45-49,59,77,90-92]
doi: 10.1186/s12987-020-00230-3 40
Although its functions are complex and remain the subject of current research, glutathione is thought to play crucial roles in the detoxification and antioxidant systems in cells
Oral Glutathione Oral treatments and supplements provide systemic antioxidant protection by optimizing glutathione levels and augmenting absorption
It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects