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Endothelial cells associated with tumors secrete growth factors such as vascular endothelial growth factor (VEGF), Notch ligands, and nitric oxide, which enables the cancer cells proliferation and self-renewal (127)

10.1016/j.bbamcr.2012.05.002 17 FangF.LuoZ

Given that cystine starvation activated the GCN2-eIF2-ATF4 axis, we evaluated the expression of several AARE-containing genes

Use a mixture of phosphate buffer (prepared by dissolving 6.81 g of potassium dihydrogen phosphate in 1000 mL of water and adjusting the pH to 4.7 with sodium hydroxide test solution) and acetonitrile (35:65) as the mobile phase