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The beneficial effect of TZT in T2DM and obesity is related to direct activation of GIP and GLP-1 receptors with subsequent improvement of insulin sensitivity and reduction of body weight
A 2026 study published in Cell Reports Medicine found that while absolute muscle mass does decrease on GLP-1s, relative muscle mass and strength actually improve , and running performance gets better, not worse
One of their tests involved feeding people omnivores and vegetarians L-carnitine (in steak and in supplements) and examining the results, when intestinal microbes were intact and after administering an antibiotic to wipe out the bacteria
In particular, coordinated tubular death and longitudinal propagation along nephron segments have been documented in both ex vivo tubular systems and in vivo murine ischemia-reperfusion models, allowing relatively strong mechanistic inference
And Im happy to say hes gone back to eating a lot of fiber again
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