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The complexity and heterogeneity of complex I disorders can be emphasized by the constellation of disorders termed MELAS, mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes

The concept originated in early-phase drug development, where sub-therapeutic doses are given to study a drug's behavior in the body without producing clinical effects

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Subcutaneous administration of one-time semaglutide 0.25 mg or 0.5 mg reached C max in 42 h and 56 h, respectively

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