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Kerner J, Yohannes E, Lee K, Virmani A, Koverech A, Cavazza C, et al

Additionally, the leave-one-out analysis revealed that removing individual SNPs did not substantially alter the overall causal effect estimates (Supplementary Figure S4)

Subsequently, nucleus translocation of PARP1-dependent AIF interacts with macrophage migration inhibitory factor (MIF) to format the AIF-MIF complex, which further induces the DNA breakage and ultimately results in parthanatos [140]