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Bonavita, E

Under conditions of compromised mitochondrial function, the PMF falls below the threshold required for ATP synthesis and the activity of ATP synthase can actually reverse such that it hydrolyzes ATP to pump protons back into the inner membrane space

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L-carnitine supplementation in such individuals may prevent or reduce high ammonia levels ( hyperammonemia ) and the severity of liver and brain damage, according to some clinical trials [27]

doi: 10.1210/jcem.83.4.4744 136 MaccarioMVeldhuisJDBroglioFVitoLDArvatEDeghenghiRet al