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It also delays gastric emptying, inhibits glucagon release from pancreatic alpha cells, causes the proliferation of beta cells, and decreases their apoptosis
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Before the introduction of the concept of ferroptosis in 2012, lipid peroxidation was believed to reduce the fluidity of spermatozoal membranes, affect the quality of spermatozoa, and disrupt membrane fusion during sperm-egg binding [72, 73]
While its expression pattern varies across tumor types, CHAC1 is frequently upregulated in aggressive malignancies, such as breast and ovarian cancer, where it correlates with advanced tumor differentiation and potentially serves as a prognostic marker
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