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The further synergistic combination approach with other gastrointestinal hormones and creation of dual GIP/GLP-1 receptor agonists, such as tirzepatide and GLP-1/GIP/glucagon receptor triagonist, retatrutide, has shown unprecedented pharmacologically achieved weight loss with further cardiometabolic benefits in both obesity and T2DM
There is no evidence to support regular calcitonin testing (a tumour marker for medullary thyroid carcinoma) or thyroid ultrasound surveillance in asymptomatic patients taking these medications
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