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Alternative pharmacological options may be considered for patients who cannot continue GLP-1 therapy but require ongoing medication support
Low end (~100200 mcg/day): ~23 vials Mid (~300600 mcg/day): ~46 vials High (up to 900 mcg/day): ~810 vials Insulin Syringes (U-100, 1 mL) Per injection: 1 syringe 12 weeks (1 daily): ~84 syringes 12 weeks (3 daily): ~252 syringes Bacteriostatic Water (10 mL bottles) Use ~3.0 mL per 10 mg vial for reconstitution
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Tip: The gradual dose titration schedule (starting at the lowest dose and increasing every 4 weeks) is designed to minimize side effects
When administered, semaglutide binds to GLP-1 receptors in the pancreas, stimulating insulin secretion in a glucose-dependent mannermeaning it only triggers insulin release when blood glucose levels are elevated
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