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Increased resistance to nitrogen mustards and antifolates following in vitro selection of murine fibroblasts and primary hematopoietic cells transduced with a bicistronic retroviral vector expressing the rat glutathione S-transferase A3 and a mutant dihydrofolate reductase

Drink at least 810 glasses of water daily, and increase intake on injection days or when headaches begin

This is why the dose window matters so much

Discontinue use and consult a healthcare provider if any unusual symptoms appear

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