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Tesamorelin activates the GHRH receptor (a class B G-protein-coupled receptor), triggering a cAMP-PKA signaling cascade that upregulates growth hormone gene transcription and increases somatotroph sensitivity to subsequent secretagogue signals
Hygroscopic, Refrigerator, under inert atmosphere solubility DMSO (Slightly), Methanol (Slightly) form Solid pka 9.830.15(Predicted) color White to Off-White Sequence Hexanoyl-Tyr-Ile-Ahx-NH2 InChIKey ADWKPLXLPNPJTR-JTJYXVOQSA-N SMILES C(N)(=O)[C@H]([C@@H](C)CC)N(C(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)CCCCC)CCCCCC(N)=O Description Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met
It is available in capsule, liquid, or injectable form
Gastroenterology 136 , 863871 (2009)
Activation of Nrf2 and a subsequent induction of GCL have been reported for various oxidants and electrophiles such as DEM, H 2 O 2 , quinones, 4-hydroxynonenal, methyl mercury, arsenicals, and plasmonic gold nanoparticles (Zhang et al
