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GLP-1 weight loss isn't linear
The release of mitochondrial DNA (mtDNA) activates the cGAS-STING signaling axis, which then triggers macrophages in RA to secrete tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and interleukin-6 (IL-6) [21]
Patients with longstanding type 2 diabetes often have substantial beta-cell loss, which can vary among individuals, potentially limiting their capacity to increase insulin secretion even with dual GIP/GLP-1 receptor stimulation
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