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J Clin Endocrinol Metab (2004) 89(3):14814

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In addition, the dual InsR/IGF-IR inhibitor linsitinib can prevent the emergence of breast cancer cells that are resistant to long-term estrogen deprivation or antiestrogen treatment and inhibit growth of established ER+ breast cancer xenografts in ovariectomized mice [107]

99 multiple modifiers may be necessary (e.g., 62 for cosurgeon, 80 for assistant, Q0 for investigational procedure in clinical trial)