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Glutathione, a tripeptide of cysteine, glycine, and glutamic acid, neutralizes free radicals and regenerates other antioxidants like vitamins C and E, preventing cellular damage that leads to aging and disease
Moreover, mitochondrial dysfunction and related oxidative stress can activate the innate branch of the immune system, leading to the release of pro-inflammatory cytokines influencing various depression-related pathophysiological mechanisms: monoaminergic neurotransmission disruption, tryptophan degradation toward neurotoxic catabolites, glutamate-related excitotoxicity, decreased neurotrophic factors and alterations in the hypothalamic-pituitary-adrenal axis [3, 33, 59]
In SURMOUNT-1, 57% hit 20% at the highest dose
These adults were given either 2.4mg of semaglutide (Wegovy) weekly or a placebo for an average of about three years
Image courtesy of Parade At the time, being in my late 20s, I felt as if I should have been aging into my 50s to 60s
