gip tirzepatide meaning modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the receptor Tirzepatide (Zepbound)

What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation

On ne sait pas encore clairement si cet avantage lemporte sur les risques (voir plus loin)

With the right support and expectations, semaglutide can be an effective tool for long-term weight management

Then you notice something else

(Figure 5A, 5B)