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Int J Mol Sci 23(9):117

Diabetes can damage nerves and cause electric shocks in legs

Notably, deletion of GPX4 caused severe phenotypic abnormalities in mice in animal experiments, whereas deletion of the ALOX12 gene did not cause major developmental defects in mice

Collectively, these systems exemplify how SEDDSs/SMEDDSs enable multifaceted urate control through bioavailability optimization and pathophysiological targeting, offering superior efficacy-to-safety ratios compared to conventional formulations