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However, the lack of a clearly defined primary molecular target and the complexity of the peptide mixture present significant challenges for mechanistic understanding and clinical translation

Similarly, mutations in the Foxp3 gene, which controls Treg development, cause IPEX syndrome, a devastating autoimmune condition affecting multiple organ systems

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But given the commonalities between primates and people, the data indicates it may be time to start human trials. And he stressed that it is very early days still: We first need to establish safety and dosing for humans

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