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In contrast, pharmacologically decreasing the biosynthesis of glutathione leads to increases in cytosolic glutamate and enhanced mEPSC frequency

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On the other hand, changes in bone are more nuanced

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Professional bodies have also responded: in July 2025 the International Society for Pharmaceutical Engineering (ISPE) issued a new GAMP Guide on Artificial Intelligence , providing a holistic framework for AI in GxP-regulated environments and emphasizing patient safety, product quality, and data integrity ( [23] ) ( [24] )