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This dysbiosis extends to liver disease, where endogenous ethanol-producing bacteria, including S.m , are enriched in the stools of NASH patients (Mbaye et al., 2023)
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Methylglyoxal (MGO), a glycolysis byproduct, interacts with glutathione (GSH) via glyoxalase 1 (GLO1) to generate lactoylglutathione (LGSH)
By comparison, injectable GLP-1 drugs have produced weight loss of more than 20% in trials, while the Wegovy pill showed average weight loss of up to 17% on the highest dose
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