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Methods Trial design and participants This phase 3, randomized, double-blind, placebo-controlled study was conducted at 41 sites across five countries (Canada, Italy, Hungary, Spain and the United States), as described in a previous publication 8 and listed in the Supplementary information

2.3.1 Background ALS is a serious and progressive disease that damages both the upper and lower motor neurons, which are the nerve cells that control voluntary muscle movement

Several small molecules targeting the APJ receptor have progressed to clinical evaluation but were discontinued due to insufficient superiority over the standard of care

& Strmer, T

Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation