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Niu L-G, Sun N, Liu K-L, Su Q, Qi J, Fu L-Y, et al
L-carnitine is a key nutrient in cellular metabolism whose main function is to transport fatty acids into mitochondria to be metabolized and used for cell energy production [1]
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The aims of this review are (1) to provide an overview of the clinical and biological overlap between neuropsychiatric long COVID and other fatigue-associated neuropsychiatric disorders, (2) to examine the shared molecular mechanisms of fatigue and depressive symptoms involving acetylcarnitine metabolism, and finally (3) to review the current evidence on acetylcarnitine supplementation studies as a treatment for fatigue-associated syndromes and pharmacological aspects of acetylcarnitine supplementation to provide a conceptual foundation for acetylcarnitine supplementation in neuropsychiatric long COVID syndrome
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