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Systemic Site of Action The large surface area of the lungs (70 m 2 in an adult) available for absorption can lead to a rapid increase in systemic concentration and hence rapid onset of action at distant effect sites

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Animals subjected to in vivo microdialysis had another guide cannula (SciPro Scientific Products & Equipment, Ontario, Canada) inserted into the following coordinates (AP + 2.2 mm, LM + 1.2 mm, DV 5.6 mm from bregma) to measure extracellular dopamine level in the core region of nucleus accumbens

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