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Expected Approval Timeline Based on Phase 3 trial completion estimates and typical regulatory review timelines, FDA approval is projected for late 2026 to early 2027

Frantz et al., 2009

Hormonal changes such as shifts in IGF-1, cortisol, or appetite levels can occur depending on the peptide

The mechanisms of GLP-1 medications (reducing appetite, slowing gastric emptying, improving insulin sensitivity) work independently of thyroid hormone status

Because semaglutide stays active for so long, taking your shot one day early typically does not create safety concerns or dramatically alter your treatment outcomes