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Cell 186 , 17081728 (2023)

In the lungs, after entering in type II alveolar cells, SARS-CoV-2 infected cells become defective for surfactant production (Ghati et al., 2021) and release cytokines, like IL-8 among others, which in turn activate alveolar macrophages to release IL-1, IL-6, and TNF-, that induce natural killer and dendritic cell differentiation and macrophage M1 polarization, enhancing the proinflammatory response with increased vasodilation causing neutrophil and activated T cell influx from the capillaries into the alveolus, all leading to the cytokine storm (Carcaterra and Caruso, 2021

As a result, initially, a goiter may be formed

In one event where a 71-year-old PD subject was subjected to FMT, improvement in bowel regularity was noted, and tremors disappeared for 2 months after the process (Huang et al., 2019)

It removes an inhibitor (CXXC5), allowing the existing pathway to function normally