One of its main, and positive side effects, is weight loss and now, its been promoted as the new magic pill for not just those suffering from type 2 diabetes, but also for overweight and obese individuals
By inhibiting proximal tubular sodium and glucose reabsorption, SGLT2 inhibitors increase distal sodium delivery to the macula densa and restore tubuloglomerular feedback, with the effect of decreasing intraglomerular pressure, shear stress, hyperfiltration and albuminuria [912]
In my experience reviewing the pharmacokinetic data from Eli Lillys Phase 2 trials, this number is consistent and well-supported
Additionally, durability of effect requires ongoing treatment, with weight regain typically occurring upon medication discontinuation
These may be mild or severe and can be treated with over-the-counter pain relievers