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Bromodomain and Extra-Terminal Domain Bromodomain Inhibition Prevents Synovial Inflammation via Blocking Ib Kinase-Dependent NF-b Activation in Rheumatoid Fibroblast-Like Synoviocytes

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Drug solutions, typically 5 mg/ml in HPLC-grade water (except for Dihexa, prepared in DMSO), were added to rat serum, and the mixture was incubated at 37C