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POTS and Orthostatic Intolerance: By facilitating the livers clearance of circulating histamine, glutathione reduces inappropriate vasodilation and blood pooling, helping to stabilize blood pressure and reduce the compensatory rapid heart rate associated with dysautonomia

Animal studies show that when circadian rhythm is dysregulated, the levels of Nrf2 and glutathione are lower.[ref] Nrf2 expression rises and falls over the course of the day

This systemic effect may explain why users sometimes report benefits beyond the specific area being treated

Vitamin C can cause reactions when mixed with certain active ingredients, such as retinol and other acids

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