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Dizziness was reported in the 2023 Phase 2 trial but was less frequent than gastrointestinal adverse effects
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showed that tirzepatide 10 mg exhibited a greater reduction in the insulin resistance index HOMA2-IR compared to dulaglutide and placebo at 26 weeks [74]
The primary mechanism associated with CJC-1295 appears to involve mimicking endogenous GHRH to bind GHRH receptors on somatotrophs in the anterior pituitary gland
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