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Semax is generally considered well tolerated, but some users report side effects such as restlessness, irritability, or feeling more wired

Dosing information Usual Adult Dose for Pernicious Anemia: Initial dose: 100 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 days If clinical improvement and reticulocyte response is seen from the above dosing: 100 mcg every other day for 7 doses, then: 100 mcg every 3 to 4 days for 2 to 3 weeks, then: Maintenance dose: 100 to 1000 mcg monthly Duration of therapy: Life Comments: Administer concomitant folic acid if needed

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In the REDEFINE 1 trial, 79.6% of combination participants experienced GI events versus 39.9% on placebo