Beyond glycemic control and weight reduction, GLP-1RAs confer cardiovascular, renal, and metabolic benefits, positioning them among the most promising therapeutic options, particularly in obese patients with diabetes (111)
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Overall, results from the cardiovascular outcomes trials (CVOTs) completed for all marketed GLP-1 RAs in type 2 diabetes support a benefit in HF specifically in addition to the approved use in broad CVD risk reduction in people with type 2 diabetes ( The biology and pharmacology of GLP-1 GLP-1 is a major peptide hormone of the incretin system
These therapies not only target weight loss but also address underlying metabolic and hormonal factors that contribute to obesity and aging