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In addition to the beneficial effects on weight loss, prolonged water fasting has been shown to alter the gut microbiome [3], improve blood pressure [4, 5], and lower inflammation markers [6]
The trial also demonstrated superiority to placebo for all confirmatory secondary outcomes assessed, including pain-free walking distance at week 52, health-related quality of life (Vascular Quality of Life Questionnaire-6) at week 52, and maximum walking distance at week 57
The potential of numerous antidiabetic agents to modify neurodegenerative disease progression, both preclinically and clinically, has been assessed
The evidence is promising but requires honest framing
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