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Concretely, p300-dependent lactylation of HMGB1 facilitates its translocation into lysosomes in the cytoplasm of macrophages and release via exosome secretion, disrupting endothelium barrier function by decreasing VE-cadherin and claudin 5 expression and increasing ICAM1 expression in human umbilical cord endothelial cells (HUVECs)
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A su vez, interviene motilidad gastrointestinal por medio de eferencias vagales, retardando el vaciamiento gstrico por aumento de la motilidad pilrica y la relajacin gstrica 24
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