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A recurring integrity issue in peptide development has been premature extrapolation from animal models to humans

[242] [243] [244] Some evidence suggests that amphetamine may be more strongly modulated by ovarian sex hormones than other psychostimulants such as methylphenidate, which may result in relatively greater variability in drug response across the menstrual cycle

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doi: 10.1016/j.nicl.2023.103503

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