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Mechanism of Action for GLP-1 Interactions Several GLP-1 agonists have been approved by the US Food and Drug Administration (FDA) for treating type 2 diabetes, obesity, or both

doi: 10.1053/j.gastro.2020.08.004 171 RinellaMELieuHDKowdleyKVGoodmanZDAlkhouriNLawitzEet al

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Indeed, in physiological conditions, plasma GLP-1 has been suggested to increase not only after meals, but also in the pre-ingestive, cephalic phase, with its peak observed about an hour prior to meal initiation in rats [55]