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Beam and Hunter Guevara 2023
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Separately, in the REDEFINE 4 head-to-head trial against tirzepatide, CagriSema produced approximately 20.2% body weight reduction at 84 weeks, compared with 23.6% for tirzepatide
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this difference may result from a ~5x stronger effect produced by GLP-1 analogs, compared to DPP-4 inhibitors (Charbonnel & Cariou, 2011) No change in weight Contraindications: type I diabetes (these patients lack pancreatic beta cells) diabetic ketoacidosis (it would not be effective for treating this condition) an association between DPP-4 inhibitors and heart failure has been observed for two members of this drug class in patients with type 2 DM and atherosclerosis
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