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Historically, such behavioral complexity was viewed as a disqualifying feature for drug development, as CNS-acting agents were associated with unpredictable neuropsychiatric liability and high regulatory barriers (Bray and Greenway, 2007

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284,290,291 Importantly, the humanized monoclonal antibody J591, which targets the extracellular domain of PSMA, has an impressive application prospect in the diagnosis and treatment of PCa

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If tirzepatide improves intestinal barrier function while reducing systemic inflammation through weight loss and metabolic improvement, it could theoretically address one of the upstream drivers of autoimmune disease activity