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In a 26-week study, orforglipron demonstrated a significant dose-dependent effect on weight loss, with weight reduction ranging from 8.6% to 12.6% across various dosages, compared to only 2.0% in the placebo group

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Semaglutide may produce the following adverse side effects: Nausea/vomiting Diarrhea Stomach pain Constipation Acid reflux Heartburn If you experience these or other adverse side effects, contact your healthcare provider

Rapid weight loss may be associated with loss of lean muscle mass, and this warrants monitoring

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