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J Crohns Colitis (2012) 6(9):87180.10.1016/j.crohns.2012.01.013 155 FishbeinTMNovitskiyGLoughDMMatsumotoCKaufmanSSShettyKet alRejection reversibly alters enteroendocrine cell renewal in the transplanted small intestine

Modulating a complex system carries the possibility of unintended effects that require careful study

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1 The APA emphasizes the importance of mental health professionals to help patients navigate body image changes, identity shifts, stigma, and evolving relationships with food during treatment

There are numerous causes of these changes (including direct effects from valproate, consequences of hyperammonemia, and cerebral edema)