Human obesity development did not establish statistically significant weight-loss efficacy in the largest reported placebo-controlled trial, and the available clinical record is insufficient to establish comprehensive safety, particularly across material forms, formulations, routes, and long-term exposure
A substantial majority of BPC-157 in vivo papers originate from a single research network anchored by the Sikiric lab at the University of Zagreb
Study endpoints include epithelial-barrier function, tight-junction protein expression, inflammatory signaling, and mucosal tissue remodeling in models of intestinal inflammation, increased permeability, and chemically induced gastrointestinal injury
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