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If you are sick, then you should absolutely check with your doctor before taking any new supplement (including semaglutide, as well as probiotics and synbiotics)

R Met/Met individuals have higher synaptic dopamine and norepinephrine (because COMT clears them more slowly), which improves prefrontal cortex function and working memory but increases susceptibility to stress-related anxiety, pain sensitivity, and catechol estrogen accumulation

Cardiorespiratory fitness is improved in people that do exercise and sauna, compared to exercise alone or sauna alone

Patients who lost the most weight regained the most in absolute terms

A thorough consultation is essential to determine if this therapy aligns with your health needs and goals