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For instance, studies with Manuka and Tualang honeys show that they can arrest breast and colorectal carcinoma cells at G0/G1 or G2/M checkpoints by modulating cyclin-dependent kinases (CDK4/6) and elevating p21/WAF1 ( Figure 1 Experimental evidence from both in vitro and in vivo models supports honeys role in modulating cell cycle progression

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