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SBP reduction was mostly mediated by weight loss (7794%) in SURPASS-1, -2 and -3, while mechanisms independent from weight loss accounted for most of the tirzepatide benefit on SBP in SURPASS-4 and -5 (57 and 73%, respectively) [77]

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More recent studies, also found that semaglutide reduced visceral adiposity and associated epicardial inflammation on imaging study, suggesting that GLP-1RAs may address both skin and fat-related inflammation in PsO patients with obesity and T2DM (58)

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The doctor used the returned product personally, without documenting it