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Pending positive outcomes from ongoing and forthcoming RCTs, GLP-1 RA medications may become a pharmacotherapeutic approach for treating polysubstance use. Alcohol Addiction Among all substances, alcohol is by far the most investigated when it comes to GLP-1 RAs

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Additionally, defective insulin signaling contributes to neuronal energy deficits by decreasing glucose uptake and reducing the expression and function of glucose transporters GLUT3 and GLUT4 in the central nervous system (Schulingkamp et al., 2000)