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Staying well-hydrated and taking the supplement alongside meals or pairing with gut health supplements can further reduce any digestive issues

Starting retatrutide above the recommended dose significantly increases the risk and severity of side effects such as nausea, vomiting, and abdominal discomfort without providing a long-term benefit

The use of GLP-1R agonists was associated with fewer intra-articular injections of steroids and a lower cartilage loss velocity from the medial femoral joint, but the direct effects of GLP-1R agonist, apart from the weight loss-mediated pathway, did not reach statistical significance

doi:10.1016/S0021-9258(18)69351-2